MK-677 ( Ibutamoren )
Price range: $100.00 through $400.00
Ibutamoren (MK-677) is an investigational, orally active, non-peptide agonist of the ghrelin receptor that potently increases growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels.
Ibutamoren (MK-677) is an investigational, orally active, non-peptide agonist of the ghrelin receptor that potently increases growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels. Often used for muscle growth, better sleep, and improved recovery, it carries significant risks including insulin resistance, water retention, increased appetite, and potential cardiovascular issues, with no official approval for human consumption
- Muscle Growth & Preservation: Used for increasing muscle mass and promoting fat loss.
- Improved Sleep: Known to enhance sleep quality, potentially through its effects on the growth hormone axis.
- Increased Appetite: Mimics ghrelin, often causing significant hunger, which is sometimes used by individuals seeking to “bulk”.
- Anti-Aging & Recovery: Studied for enhancing bone density and improving body composition, especially in older adults
- Insulin Resistance & Blood Sugar: MK-677 may increase fasting blood glucose and impact insulin sensitivity.
- Increased Appetite & Water Retention: Intense, sustained hunger and significant weight gain, often due to fluid retention/swelling.
- Cardiovascular & Heart Concerns: Some trials showed concerns regarding an increased rate of congestive heart failure.
- Other Side Effects: Joint pain, numbness, fatigue, and potential increases in cortisol levels.
- Increased Prolactin: Studies show average prolactin levels can rise by up to 27%, which is considered undesirable
- Legality and Status: It is considered an “investigational new drug” and is not approved for human consumption, often sold as a research chemical.
- Doping Risk: MK-677 is classified as a “S2” prohibited substance by the World Anti-Doping Agency (WADA).
- Dosage & Effects: Users often take 10-25 mg daily, with potential muscle gains of 3–5 pounds over a 12-week period, although much of the initial weight gain may be water retention.
- Safety Data: Long-term studies on safety in humans are lacking.
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